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3-MMC Rock Por Mayor has become one of the most popular recreational drugs all over the world after the ban of mephedrone, and was lately deemed responsible for various deaths and intoxication. This study is aimed at understanding the hepatotoxicity of 3-MMC. For this reason, Wistar rat hepatocytes were isolated by collagenase perfusion, cultured and exposed for 24 hours at a density range varying from 31 nM to 10 mM 3-MMC. The modulatory impacts of 2-FDCK Por Mayor were evaluated. 3-MMC induced toxicity was perceived at the lysosome at lower densities and cytoplasmic membrane. A substantial density dependant augment of intracellular reactive species was observed on this chemical. A density dependant reduction in antioxidant glutathione defences was also observed. 3-MMC Fine Por Mayor at this density was substantially elevated, causing the activation of both intrinsic and extrinsic apoptosis pathways. Nuclear morphology and formation of cytoplasmic acidic vacuoles suggest prevalence...